New Publication: The Extra-Cellular Domain of PepT1 and PepT2 Philip Fowler, 2nd November 2015 0 shares PepT1 is a nutrient transporter found in the cells that line your small intestine. It is not only responsible for the uptake of di- and tai-peptides, and therefore much of your dietary proteins, but also the uptake of most β-lactam antibiotics. This serendipity ensures that we can take (many of) these important drugs orally. Our ultimate goal is to develop the capability to predict modifications to drug scaffolds that will improve or enable their uptake by PepT1, thereby improving their oral bioavailability. In Structure we report the structures of the extra-cellular domains (ECDs) of PepT1 and PepT2. This is an important milestone on the road to elucidating a structure of PepT1 and allows us to propose the first full-length structural model of PepT1 (see above). Intriguingly, the data also suggests that the ECD also interacts with trypsin, thereby increasing the local concentration of peptides around the transporter, improving its efficiency. Share this:Twitter Related publication research
publication New publication: Gating Topology of the Proton-Coupled Oligopeptide Symporters 3rd February 2015 [Could not find the bibliography file(s) This paper [BIBCITE%%0%] is the result of a large collaboration… Share this:Twitter Read More
antimicrobial resistance New publication: Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex 9th March 202016th March 2020 Although the population structure M. tuberculosis is clonal, one must be careful when inferring the… Share this:Twitter Read More
publication New Publication: Detailed examination of a single conduction event in a potassium channel. 15th October 2013 What can we learn using computational methods about how potassium ions and water molecules move… Share this:Twitter Read More