Atomic force microscopy (AFM) was used here to study chronic myeloid leukemia (CML) stem cells in dormant (quiescent) and proliferating stages. Persistence of residual quiescent CML stem cells (LSCs) that later resume proliferation seems to be a common cause of recurrence or relapse of CML. The collage shows a scheme of the AFM method and the found biophysical difference between these cells in the density of the pericellular layer surrounding cells.
This review gathers important and up-to-date information about variable synthetic methods that lead to attainment of magnetic nanoparticles with different shape and size. Moreover, information summarized within this manuscript determines the basics of sensing principles of magnetic nanoparticles. Furthermore here we report functionalization and modification of magnetic nanoobjects in order to achieve surfaces suitable for selective drug delivery, medical diagnosis and applications. Ultimately, one chapter is especially devoted to alternative green synthesis of nanoparticles.
Siderophores and oligopeptides take advantage of specific microbial active transport systems. Particular types of cell penetrating peptides, carbon nanotubes and terpenoid derivatives enter the cells by direct translocation. Dendrimers and large cell penetrating peptides are internalized by endocytosis. All these compounds conjugated with antimicrobials act as nanocarriers and transport the cargoes across the biomembranes. Once the conjugate is internalized, the active component could reach its intracellular target, either after release from the conjugate or in an intact form.
MPLA-coating of HBsAg nanocapsules (NCs) enhanced the uptake of NCs by neonatal and adult monocyte-derived dendritic cells (moDCs). The TLR4 mediated phagocytosis and the additional stimulation with IFN induced up-regulated expression levels of the co-stimulatory molecules CD80/86, the MHC II molecule, and the secretion of the pro-inflammatory cytokines TNF-, IL-12 and IL-6. Neonatal moDCs pulsed with MPLA-HBsAg-NCs plus IFN possessed the ability to trigger nave T cells towards TH1 immunity. The antigen-specific T cell proliferation was associated with the secretion of TH1 cell-specific IFN release.
A poly(phosphorhydrazone) dendrimer capped with amino-bis(methylene phosphonate) end groups enables the proliferation of human NK cells. This specific outcome results from a complex cross-talk between dendrimer-activated monocytes and autologous NK cells. During this crosstalk, dendrimer-activated monocytes are needed to enable the proliferation of NK cells, but ultimately, the NK cells have to kill autologous monocytes to proliferate. Like the yin and the yang, these cells have contrary but interdependent activities at the same time. This specific amplification of NK cells is also possible starting from peripheral blood of multiple myeloma patients, paving the road for NK cell-based anti-cancer immunotherapies.
The enzyme-responsive peptide drug conjugate specifically delivers the drug to prostate cancer cells. The PSA substrate is cleaved in the tumor interstitial space to release the dipeptide-linked TGX-D1, which enters the cells via overexpressed dipeptide transporters in prostate cancer cells. TGX-D1 is finally released from the dipeptide after cleavage of the ester linker inside the cells to exert its pharmacological effect. The intact peptidedrug conjugate may also enter the cells directly via endocytosis, and the ester bond can be cleaved inside the cells to release the active drug.
Overall properties and applications of synthesized magnetic nanoparticles coated by amphotericin B (red balls) or nystatin (blue balls) or their mixture against Candida cells.
Hydrophobic core protected graft copolymers (HC-PGC) such as MPEG-gPLL acylated with oleic acid, promote the formation of nanoparticles of water-insoluble benzophenone-uracyl non-nucleoside reverse transcriptase inhibitors after the co-lyophilization. These nanoparticles bind to the surface of HIV-1 infected effector cells and result in a high selectivity anti-HIV index because of their low toxicity.
Mice were fed with an MCD diet seven days ahead to develop NAFLD, and were then treated with saline, FNB crude drug or FNB-Nanolipo by gavage and meanwhile continuously fed with the MCD diet for another seven days. Compared to the FNB crude drug, the FNB-Nanolipo significantly enhanced oral absorption of FNB and therefore, significantly cured NAFLD induced by the MCD diet.
Iontophoresis for transcutaneous immunization using ovalbumin (OVA) as a model antigen, liposomes and silver nanoparticles (NPAg): in vitro iontophoresis of the liposomal dispersion containing NPAg improved OVA penetration into the viable epidermis, where antigen presenting cells are located. This increase in OVA skin penetration resulted in a humoral immune response similar to that obtained following a subcutaneous injection of OVA. The cellular immune responses that were obtained after iontophoresis of OVA-liposomes and OVA-liposomes w/o NPAg were more evident than those obtained after subcutaneous injection.
We show that polyethyleneimine/magnetic nanoparticles based delivery vector (PEI/MNP) is suitable for production of miRNA-modified endothelial cells in terms of efficiency and safety. The obtained transfected cells can be guided to the site of interest using a magnetic field and their fate can be noninvasively traced using magnetic resonance imaging. This multifunctional approach for transient cell modification bears particular interest as a basis for clinically relevant cell engineering.
The formation of folate targeted CD nanoparticles encapsulating RelA siRNA leads to specific folate mediated uptake in PSMA+ cells, the specific knockdown of RelA and an increase in the half-life of the siRNA
The improvement of osseointegration will be a great challenge for the design of the future generation of bone implants. The application of specific nanotopographies on the surface of bone implants is a potential strategy to achieve improved quality, without the need for changes of the implant design. In the current paper, nanogrooved topographies that were reproduced into epoxy resin cylinders could significantly increase bone regeneration around the implants in a rat femoral condyle model, compared to rough control surfaces.
Different from traditional idea, we designed and synthesized a highly hydrophobic reduction-sensitive docetxel prodrug with a disulfide bond inserted into the linker between docetaxel and vitamin E, which could self-assemble in water to form self-assembled nanoparticles without the help of surface active substances. Compared with a docetaxel Tween80-containing formulation, the unique nanomedicine had many advantages, including high drug payload, advanced stability, superior reproducibility, low toxicty, prolonged circulation and increased therapeutic efficacy. The highly reproducible self-assembled nanoparticles prepared by simple nanoprecipitation technology are more attractive and effective nanomedicines, and might be a promising nano-drug delivery system for other anticancer drug.
Currently, clinical ultrasonography and serum alpha-fetoprotein have limited specificity and sensitivity for the detection of hepatocellular carcinoma (HCC). In this study, based on Au@Ag NRs nanorods surface-enhanced Raman spectroscopy(SERS), we performed a label-free, non-invasive SERS test on 230 serum samples (47 HCC, 68 breast cancer, 55 lung cancer, and 60 normal control) to identify distinctive Raman spectrum peaks as a metabolic fingerprint to predict HCC. This paper is the first to report on the detection of serum metabolic profiles in HCC patients through SERS. In addition, this study is also the first to detect and compare serum SERS in three types of cancer to determine the general serum metabolic alterations among cancer patients. Furthermore, SERS combined with orthogonal partial least squares discriminant analysis exhibited good diagnostic performance for HCC, with the receiver operating characteristic curve having an area under curve value of 0.991. The present study provides new insights into the detection of metabolic processes related to the biology of HCC through Raman spectroscopy.
Radiotherapy is a key component of prostate cancer treatment. Because of its importance, there has been high interest in developing agents and strategies to further improve the therapeutic efficacy of radiotherapy. In this study, we engineered a nanoparticle formulation of Dbait, a new class of DNA damage repair inhibitor, with H1 (folatepolyethylenimine600cyclodextrin) nanopolymer. We demonstrated that H1/Dbait nanoparticle was a potent radiosensitizer in vitro and in vivo. Our study supports further investigations using nanoparticles to deliver DNA damage repair inhibitors to improve the therapeutic index of radiotherapy for prostate cancer.
Cerium oxide nanoparticles (20mg/kg) given intravenously twice a week prolonged survival in SOD1G93A transgenic mice. Treatment was started at the onset of muscle weakness at ~113days of age.
The hallmark of chronic obstructive lung diseases, such as COPD and CF, is intermittent or stable exacerbation that initiates progression of chronic inflammatory lung disease. Although, we have made significant progress in the development of anti-inflammatory drugs to treat these diseases but in order to provide sustained drug-delivery to target cells, there is a need for nano-carrier(s) that can circumvent obstructive airway defense. Hence, in this study we evaluated the efficacy of neutrophil-targeted nanoparticle in delivering non-steroidal anti-inflammatory drug, ibuprofen to control Pa-LPS induced inflammatory lung disease and cigarette smoke induced emphysema.
Subretinal injection of SP-PA-PRPF31 nanoparticles in heterozygous knock-in (KI) Prpf31A216P/+ mice. The retinal thickness measured by optical coherence tomography (OCT) in KI Prpf31A216P/+ mice treated with SP-PA-PRPF31nanoparticles was a similar value to wild type mice. These nanomedicines not only improved visual function but also retarded or reversed retinal degeneration in KI Prpf31A216P/+ mice, evidenced by the absence of retinal atrophy.
Gold nanorods (GNRs) inhibit respiratory syncytial virus (RSV) in vitro and in vivo. The antiviral gene expression study showed interplay of Toll-like receptor, NOD-like receptor and RIG-I-like receptor signaling pathways. Transmission electron microcopy, histological investigation and cytokine analysis indicate that GNRs stimulates innate immune response resulting in RSV inhibition.
This figure shows the formation of G4AcFaHSTK compact nanoparticles from the interaction between HSTK-based plasmids and partially acetylated, folic acid-conjugated, cationic 4th-generation polyamidoamine dendrimers (G4AcFa). Also, it shows the application of the real-time PFQNM mode of AFM to visualize the morphological and nanomechanical changes of individual live and dividing HeLa cells in their native environment upon their attack by G4AcFaHSTK.
After proper oral immunization schedules using SBA-15 as adjuvant, the recruitment of inflammatory cells to Peyers patches and mesenteric lymph nodes and the enhanced production of specific antibodies, as well as the non-influence of silica in the polarization to TH1 or TH2 immune responses, were shown.
Increased levels of soluble amyloid-beta (A) oligomers are suspected to underlie Alzheimer's disease (AD) pathophysiology through the formation of uncontrolled multi-subunit A pores in cellular membranes. In this study, the efficacy of small molecule NPT-440-1 modulation of A1-42 pore permeability was examined. We show that co-incubation of B103 rat neuronal cells with NPT-440-1 and A1-42 prevented calcium influx. In purified lipid bilayers, preincubation prior to membrane introduction was required to prevent conductance despite the presence of pore structures. The results point to compound-induced structural modulation leading to collapsed pores and suggest that pharmacological modulation of A1-42 could prevent AD pathogenesis.
See original here:
Nanomedicine: Nanotechnology, Biology and Medicine ...
- Nano Medicine: Meaning, Advantages and Disadvantages - BioTechnology Notes - December 18th, 2022
- www.the-scientist.com - December 18th, 2022
- Applications of Nanotechnology - National Nanotechnology Initiative - December 18th, 2022
- Nanotechnology Timeline | National Nanotechnology Initiative - October 29th, 2022
- Nano based drug delivery systems: recent developments and future ... - October 21st, 2022
- The Application of Nanotechnology and Nanomaterials in Cancer Diagnosis and Treatment: A Review - Cureus - September 16th, 2022
- 'Glass bubble' nanocarrier boosts effects of combination therapy for pancreatic cancer - UCLA Newsroom - September 16th, 2022
- International Conference (Sep. 15-17) on Advances in Molecular Diagnostics and Precision Medicine (AMDP-2022.. - ETHealthWorld - September 16th, 2022
- Reebok Nano X2 Adventure Review: A Wild Way to Log Your Workouts - Gear Patrol - August 30th, 2022
- PhD within Particle Engineering job with NORWEGIAN UNIVERSITY OF SCIENCE & TECHNOLOGY - NTNU | 306487 - Times Higher Education - August 30th, 2022
- Nanoparticles' Role in Eliminating Cancer Cells - MedTech Outlook - August 22nd, 2022
- The first female astronaut from a North African nation will be a Tunisian military aviator - Atalayar - August 22nd, 2022
- Fast and noninvasive electronic nose for sniffing out COVID-19 based on exhaled breath-print recognition | npj Digital Medicine - Nature.com - August 22nd, 2022
- Reebok's Nano X2 Adventure Helps You Take Your Workouts Anywhere - Gear Patrol - August 14th, 2022
- How Houston's nonprofit funds early research that leads to breakthroughs like the COVID vaccine - Houston Chronicle - August 14th, 2022
- Ponce Therapeutics Executes Worldwide Exclusive License to Speratum Biopharma's Nano-in and No-Pass Mimic Nanoparticle Technologies in Anti-Aging and... - July 27th, 2022
- Nanorobots Market to close to USD 19576.43 million with CAGR of 12.23% during the forecast period to 2029 - Digital Journal - July 27th, 2022
- Aviceda Therapeutics Announces Key Opinion Leader in Ophthalmology Drug Development Tarek S. Hassan, MD to Join Management Team as Chief Development... - July 27th, 2022
- Second Sight Medical Products Announces Year Four NIH Funding of its Orion Study - Business Wire - July 19th, 2022
- Columbia Business School and Columbia Engineering to Offer New "Dual MBA/Executive MS in Engineering and Applied Science" Program - Yahoo... - July 19th, 2022
- Internet of Nano Things Market is Poised to Grow at a CAGR of 24.12% during the Forecast Period of 2022-2031 - Digital Journal - July 11th, 2022
- Notable Thermal and Mechanical Properties of New Hybrid Nanostructures - AZoM - July 11th, 2022
- Eggshell and bioceramics: Break an egg to fix a tooth or two - BusinessLine - July 11th, 2022
- Nanomedicine in Central Nervous System Injury and Repair Market Share, Regional Growth Analysis, Upcoming Trends, Growth Factors and Leading... - July 11th, 2022
- Nanorobotics Market 2022 Research Report Analysis from Perspective of Segmentation and Industry Growth 2030 Designer Women - Designer Women - July 11th, 2022
- Artificial Intelligence in Medical Diagnostics Market Worth $9.38 Billion by 2029 - Exclusive Report by Meticulous Research - GlobeNewswire - July 11th, 2022
- $2.38M to test nano-engineered brain cancer treatment in mice - University of Michigan News - June 22nd, 2022
- New Amrita Hospital is all set to open in Faridabad in August this year; 2,400-bed facility will become Indias biggest private hospital - The... - June 22nd, 2022
- Global Advanced Functional Materials Market To Be Driven By The Surging Demand From Medical Sector In The Forecast Period Of 2021-2026 Designer Women... - June 22nd, 2022
- An effective nano drug delivery and combination therapy for the treatment of Tuberculosis | Scientific Reports - Nature.com - June 13th, 2022
- Nanotechnology is poised to shape the future of Healthcare - ETHealthWorld - June 4th, 2022
- New Silence ALS Initiative is Giving Hope to Nano-Rare Patients - BioSpace - June 4th, 2022
- Nanotechnology in the Global Medical Applications Market 2022, Featuring Profiles of Abbott, Abraxis Bioscience, Elan, Orthovita, EyePoint... - May 15th, 2022
- Nano state: tiny and now everywhere, how big a problem are nanoparticles? - The Guardian - May 2nd, 2022
- Nanomedicine Market to 2030 Insights and Forecast with Impact of COVID-19 | Abbott Laboratories, DiaSorin S.p.A, Invitae Corporation, Mallinckrodt... - May 2nd, 2022
- Cancer and Nanotechnology - National Cancer Institute - April 19th, 2022
- Nanobots/Nanorobots Market Overview, Merger and Acquisitions , Drivers, Restraints and Industry Forecast By 2028 - Digital Journal - April 19th, 2022
- ERDC researchers analyze resilience in nanotechnology supply chains - erdc.usace.army.mil - April 19th, 2022
- Nano Products Online Store | Nanoproducts, Nanoparticles ... - April 6th, 2022
- The Conrad Prebys Foundation to Support the Discovery and Development of Personalized ASO Medicines for Nano-rare Patients - Business Wire - March 25th, 2022
- Space the next frontier for cancer treatment? - Australian Jewish News - March 25th, 2022
- ViaCyte Strengthens Management Team with Appointment of Alyssa Levin as Chief Financial Officer and Addition of Lisa Porter, MD, to the Board of... - January 20th, 2022
- Surface Modification and Size Contribute to Nanoplastic Toxicity - AZoNano - January 20th, 2022
- Frontiers | Nanomedicine: Principles, Properties, and ... - January 5th, 2022
- Nanotechnology In Medicine: Huge Potential, But What Are ... - January 5th, 2022
- Stem Cell Mimicking Nanoencapsulation for Targeting Arthrit | IJN - Dove Medical Press - January 5th, 2022
- 2009 show based on conspiracy theories is shared as proof of WHO working on COVID-19 vaccines to create permanent sterility - Factly - January 5th, 2022
- How to Improve Infectious Diseases with Nanotechnology - CIO Applications - January 5th, 2022
- Biodistribution of sphingolipid nanoemulsions with 68Ga | IJN - Dove Medical Press - August 31st, 2021
- Matrix Meats Adds to Team as Interest in Cultivated Meat Grows - PRNewswire - July 21st, 2021
- Nanomedicine in Central Nervous System Injury and Repair Market Report- Trends Key Programs Analysis and Competitive Landscape Analysis The Manomet... - June 23rd, 2021
- Nanomedicine is transforming healthcare innovation - Korea IT Times - June 6th, 2021
- The Future of Cancer Treatment Using Nanotechnology - AZoNano - June 6th, 2021
- Thomas Jefferson Awards Highlight Research and Service to the University - UVA Today - June 6th, 2021
- Global Nanobots Market 2020 | Research Report Covers | (COVID-19 Analysis) | Industry Research, Drivers, Top Trends | Global Analysis And Forecast to... - October 31st, 2020
- Nanox Signs With Ambra Health to Enable Image Access and Transfer with US Hospitals and Medical imaging Providers - BioSpace - October 31st, 2020
- Global Nano Therapy Market- Industry Analysis and Forecast (2020-2027) - Stock Market Vista - October 29th, 2020
- What is Nanoscience? | Outlook and How to Invest | INN - Investing News Network - September 23rd, 2020
- Interview: The NDB team on its revolutionary nano-diamond batteries - New Atlas - August 29th, 2020
- Opportunities in the World Nanotechnology Market to 2025 - Application of Nanotechnology in Wastewater Treatment and Enhanced Renewable Energy Driving... - August 12th, 2020
- Cellics Therapeutics Announces the Publication of Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity in Nano Letters - BioSpace - June 17th, 2020
- Nanocellulose Market to Reach USD 1.08 Billion by 2027 | CAGR:20.4% | Reports And Data - PRNewswire - June 17th, 2020
- Coronavirus threat to global Healthcare Nanotechnology (Nanomedicine) Market 2020 Industry Share, Size, Consumption, Growth, Top Manufacturers, Type... - June 15th, 2020
- Kanazawa University Research: Cell Removal as the Result of a Mechanical Instability - PR Newswire UK - June 15th, 2020
- Impact of Covid-19 on Nano Chemotherapy Market is Expected to Grow at an active CAGR by Forecast to 2026 | Top Players Dell Wyse, IBM, Microsoft -... - June 15th, 2020
- Evergreen Medical Acupuncture is now offering its own supplement and herbal products, Dr. Ficks Functional Farmacy! - TippNews DAILY - June 10th, 2020
- Inolife is going to revolutionize how we take our medicine - BNNBloomberg.ca - May 24th, 2020
- Recent Progress and Future Directions: The Nano-Drug Delivery System f | IJN - Dove Medical Press - May 10th, 2020
- The future of medicine - Switzer Financial News - May 10th, 2020
- All your questions about how to wear a face mask -- answered - Action News Now - April 26th, 2020
- Edited Transcript of NANO earnings conference call or presentation 6-Feb-20 9:30pm GMT - Yahoo Finance - February 11th, 2020
- Kanazawa University Research: Combined Drug Treatment for Lung Cancer and Secondary Tumors - Yahoo Finance - February 11th, 2020
- Immix Doses First Patient in USA in its Phase 1b/2a Trial in Patients with Advanced Solid Tumors - BioSpace - February 11th, 2020
- Nano Medicine: Meaning, Advantages and Disadvantages - February 6th, 2020
- The Future Of Nano Medicine - February 6th, 2020
- VVUS Stock Jumps 70% on FDA Nod for New Formulation of Pancreaze - MicroSmallCap - February 6th, 2020
- Is the Lieber Arrest Linked to Military Brain Research and China? - Bryen's Blog - February 6th, 2020
- A Chelate-Free Nano-Platform for Incorporation of Diagnostic and Thera | IJN - Dove Medical Press - January 10th, 2020
- Examine Triple Negative Breast Cancer Treatment Market expected to reach US$ 720 mn by 2026 - WhaTech Technology and Markets News - January 10th, 2020
- Triple Negative Breast Cancer Treatment Market Combining Therapies - Communal News - January 10th, 2020